The title 25 or 6 to 4 may sound cryptic, but it really it wasn't meant to be, according to Chicago saxophonist Walter Parazaider. “That’s a song about writing a song. Robert Lamm wrote it and I was asked on an interview to England one time, ‘I say, we’ve got this figured out here, old chap – it’s odds on a horse race.’ And other people thought it was something about a drug song, or whatever. And all it was Robert was writing a song and he looked and it was 25 or 6 to 4 and he was having a rough time finishing the song and he didn’t know whether he should go to sleep or finish the song. As simple as that ladies and germs.”
25 or 6 to 4 off Chicago’s second studio album peaked at #4 on the Billboard Hot 100.